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Among them, the absence of BMAL1 as a core clock gene in the intestinal epithelium (such as in the Bmal1 ablation model) will disrupt the rhythm of the microbiota and weaken the expression of BMAL1-dependent antioxidant defense and cognition-related genes, leading to cognitive dysfunction

Kruis W, Fric P, Pokrotnieks J, Luks M, Fixa B, Kasck M, et al

Intervention and Placebo the intervention group received cysteine-rich whey protein isolate (CRWP), commercially available as Immunocal, which was provided by Immunotec Inc

References: Cherney K

sCAR Lastly, extracellular scFv fused to inhibitory signaling domain can specifically inhibit CAR T cell activation