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and the use of antivirals that enhance activation of the Nrf2 transcription factor together with N-acetylcysteine administration restore GSH levels correcting the SARS-CoV-2-mediated impaired GSH metabolism (Aquilano et al., 2014

Firstly, lactate produced in active muscle tissue can be reused for glucose formation in the liver, completing the Cori cycle and enabling gluconeogenesis (149)