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Notably, individuals with erythropoietic protoporphyria have been shown to have lower serum -carotene levels and may require dietary supplementation to mitigate symptoms [2]

The immune system appears to play a pivotal role in these conditions, with evidence of T-cell and B-cell dysfunction, including signs of exhaustion in ME/CFS

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El Mestikawy S, Walln-Mackenzie A, Fortin GM, Descarries L, Trudeau LE

van VlietTVarela-EirinMWangBBorghesanMBrandenburgSMFranzinRet alPhysiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression