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Results showed that the penetration level of diethyldithiocarbamate (DDC), the primary metabolite of DSF, was approximately 1.3 times higher in MC-based eye drops than in plain drops [63]

Another area of growing interest is the role of astrocyte-neuron interactions in maintaining GSH homeostasis: astrocytes synthesize GSH by importing cystine via the cystine/glutamate antiporter (Sxc ) and glutamine synthetase, releasing GSH directly through pannexin-1 channels or gap junctions (Cx43), while regulating extracellular glutamate levels via excitatory amino acid transporter 1/2(EAAT1/2) transporters to sustain neuronal GSH precursor supply, thereby mediating neuroprotection under oxidative stress (Verkhratsky and Nedergaard, 2018)

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A series of images were acquired every 26 h with a 10X objective lens in phase contrast and green fluorescence (Ex/Em: 460/524 nm with an acquisition time of 200-400 ms)

demonstrated that increased expression of MMP-7 was inversely related to claudin-7 expression in murine models and IBD patient tissues