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doi: 10.3389/fmicb.2025.1642377 Received 06 June 2025 Accepted 30 September 2025 Published 21 October 2025 Volume 16 - 2025 Edited by Guiguo Zhang, Shandong Agricultural University, China Reviewed by Xiao Ma, Chengdu University of Traditional Chinese Medicine, China Xiaoyong Yu, Shaanxi Provincial Hospital of Traditional Chinese Medicine, China Updates Copyright 2025 Li, Diao, Li, Huang and Sun

417 Oxidized mtDNA is released into the cytosol via mPTP and VDAC-dependent channels on mitochondria, activating the NLRP3 inflammasome and driving a range of inflammatory diseases