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If you have received a coronary stent, you should consult with your clinician before having B12 injections as certain interactions between B12 and other vitamin supplements can increase the risk of blood vessel narrowing

17 Note: Inhalation dosing is typically 600mg/dose in 4-8mL of water

For younger, healthier, lighter individuals, titration runs cautiously pushing past the efficacious dose tends to bring on undesirable side effects

BMJ Case Rep 2011, 2011

Additionally, 50 healthy elderly subjects received either placebo (n = 20) for 4 weeks or 25 mg of MK-677 (n = 30) daily for 2 weeks followed by 50 mg daily for 2 weeks