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Reactive oxygen species (ROS)

In an effort to maintain electron balance, these free radicals will steal electrons from neighbouring molecules, which prevents the molecule from functioning normally

Many small-molecule synthetic antioxidants (such as vitamin C and N-acetylcysteine) have shown limited effectiveness in clinical trials for sepsis, primarily because they neutralize ROS at a 1:1 stoichiometric ratio and become ineffective once depleted

These findings suggest that suppressing ammonia accumulation in immune cells or targeting ammonia-induced cell death pathways may represent a promising strategy to prolong Teff survival and optimize CAR-T therapy

Given the evidence highlighted above, it is plausible that additionally to providing faster and essential (given the depletion of glucose) fuel for the brain, KBs will, through their membrane stabilization properties and anxiety-reducing effect [139] lead to a state of reduced anxiety, facilitating a vicious cycle that will persist due to these positive effects