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Description

Management of irAE typically includes high-dose corticosteroids, with immunosuppressive therapies in severe cases [26]

Preparation of C11-substituted analogs of mitragynine and related scaffolds The 11-boronate ester ( 4a ) was converted to the compounds 11-Cl-MG-EG ( 13 ) and 11-OH-MG-EG ( 14 ) using the appropriate substitution methods (Fig