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doi: 10.3892/etm.2015.2908 138 ZhaiWMaZWangWSongLYiJ

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

In Huh7, AA suppressed the protective upregulation by OCA or GW4064 of BSEP and SHP, and when STAT3 was knocked down by siRNA ,then the expression was further suppressed