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Abbreviations PD: Parkinson disease NRF2: Nuclear factor erythroid-2 related factor 2 keap-1: Kelch-like ECH-associated protein 1 NLRP3: NLR family pyrin domain containing protein 3 ROS: Reactive oxygen species HO-1: Heme oxygenase 1 TXNIP: Thioredoxin interacting protein NF-B: Nuclear factor kappa B IL: Interleukin NQO1: NADPH quinone oxidoreductase-1 GPx: Glutathione peroxidase CBP: CREB binding protein IKK: Inhibitory kappa B kinase ARE: Antioxidant response element TRAF6: Tumor necrosis factor receptor associated factor 6 RIP1: Receptor interacting protein P-62/(SQSTM1): Sequestosome 1 CARD: Caspase recruitment domain CK1: Cysteine kinase 2 MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine LPS: Lipopolysaccharide References GBD 2016 Neurology Collaborators

The peptide portion binds copper(II) ions with high affinity through its histidine and glycine residues, forming a stable complex that has shown remarkable activity in gene expression studies across many cell types

[DOI] [PubMed] [Google Scholar] Gheibi S, Jeddi S, Kashfi K, Ghasemi A (2018)

Unfortunately, unlike roGFPs measuring the redox potentials of GSH/GSSH, peroxynitrite and GSH are not a redox pair and the biological meaning of the ratio of these two species is elusive

619 Overall, DNA methylation levels decrease in SLE patients, and disease activity and progression in lupus patients are negatively correlated with methylation patterns, 620,621 primarily due to the reduced expression/activity of DNMTs