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(1) Studies on the Validation of In Vivo Obesity Intervention Effects A large number of in vivo animal experiments have confirmed that it exerts significant weightloss and fatreducing effects with favorable safety profiles.In a mouse model of highfat dietinduced obesity, administration of 20 mg/kg NNMTi daily for 11 days resulted in a significant reduction in body weight

41 In recent years, research on the differential genes expression and associated pathways in ARDS patient phenotypes has revealed that elevated plasma lactate levels are associated with oxidative phosphorylation and increased gene expression, potentially caused by mitochondrial dysfunction and alterations in energy metabolism 42 (Figure 1)

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Furthermore, necroptotic inflammation is also considered an important driving factor for kidney graft failure