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Recreational nitrous oxide use: Prevalence and risks

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Around 1520% of patients with IBD demonstrate hypermethylation when treated with thiopurines, resulting in preferential metabolism of MP to methylmercaptopurine (MeMP)[54]

For example, it may influence pathways that either upregulate the expression of enzymes involved in the lipolysis process or enhance the cellular response to lipolytic signals by modulating the activity of secondary messengers within the cell