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First, the intrinsic-factor route saturates: only about 1.5 to 2 micrograms of B12 can be absorbed per meal through cubam, which is why any single receptor or carrier defect has a ceiling effect and why very large oral doses partly bypass the system through slow passive diffusion (roughly 1% of an oral dose)

McKnight first shared the admission on a podcast, then posted a longer statement to Instagram after renewed debate around BPC-157