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HDACs serve as critical modulators of protein post-translational modifications (PTMs), which represent essential biochemical processes that dynamically regulate protein structure and function through covalent modifications following protein synthesis

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These studies highlight that PPEs biocompatibility and bioactivitiessuch as antibacterial and anticancer propertiesendow nano-drug carriers with excellent compatibility and the ability to inhibit bacterial and cancer cell growth

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Although these therapeutic strategies are still in development, they have the potential to suppress ALS progression by directly targeting specified glial cell populations, applying Treg, and suppressing age-associated chronic inflammation (Gendron and Petrucelli, 2023)