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Name: what is the studied dose of l-carnitine Supplementation in Recovery after Exercise L-carnitine: benefits, intake, dosage and
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The synthetic lethality between BRCA mutations and PARPi arises from the simultaneous disruption of two critical DNA repair pathways: (i) BRCA1/2 loss abolishing homologous recombination (HR) and (ii) PARPi blocking base excision repair and trapping PARP-DNA complexes, leading to catastrophic genomic instability in cancer cells while sparing normal cells with intact HR