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Description

Such intricate PK/PD behavior substantially complicates dose optimization and represents a key bottleneck in translating PROTACs from bench to bedside [117,118,119,120]

Two replicates from each cell line were seeded at 0.25 10 6 cells per ml and treated with 0.5 mM LLOMe hydrochloride (Cayman Chemicals, 16008) or 0.01% DMSO mock treatment for another arm of the screen (not shown) and cultured for 2 days