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Lead binds to protein sulfhydryl groups, depletes GSH, and enhances lipid peroxidation, while thallium damages mitochondrial function and increases ROS generation [77]

10.1016/j.it.2014.04.007 146

Intriguingly, these same glycolytic changes are observed in PBMCs from those with rapid eye movement (REM) sleep behavior disorder (RBD), a group generally considered to approximate prodromal PD due to their high likelihood of converting to PD or related synucleinopathies [31]