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This metabolite promotes TME acidity, suppressing the local immune response [90]

showed that the rs28674628 is significantly associated with earlier age of diagnosis and increased BrCa risk among Jewish BRCA1 mutation carriers [77]

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For instance, overexpression studies have found that ME1 promotes cancer growth and metastasis via NADPH homeostasis in various cancers including gastric cancer, basal-like breast cancer and lung cancer, etc