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The six-transmembrane epithelial antigen of the prostate (STEAP) facilitates this process by reducing divalent Cu 2+ to Cu +

[138,139] NAC may have a role, however, in the reversal of renal toxicity due to cisplatin

In fact, zonulin and claudin-5 have been proposed as biomarkers to detect BBB disruption [140] now that a diminished BBB integrity has been observed in patients with intestinal inflammation [148]