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Patients following bariatric surgery, GI disease, or with malabsorption syndromes

A.HallR

That is, if a generic Part D rebatable drug that is currently in shortage from September 15, 2025, until May 15, 2028 receives a 75 percent reduction under the shortages policy for the applicable period that begins October 1, 2024, receives a 75 percent reduction under the severe supply chain disruption policy for the applicable period beginning October 1, 2025, then CMS would apply a shortage reduction percentage of 25 percent to the applicable periods beginning October 1, 2026 and October 1, 2027

These microbial shifts trigger cascading gutbrain disruption by impairing neurotransmitter signaling, suppressing SCFA production, weakening epithelial barrier integrity, and activating neuroimmune pathways, ultimately resulting in anxiety- and depression-like behaviors in rodent models (Tejkalov et al., 2023