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For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle

Safety data also remains incomplete, particularly for long-term use, high-dose exposure, and potential interactions with commonly used medications

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PlexusDx emphasizes how genetic insights into peptide sensitivity, combined with clinical assessment, can support more informed conversations with healthcare providers about treatment suitability and monitoring

Additionally, others may have mutations in their GPX/GST and other genes that put them at risk for low glutathione levels or higher oxidative stress levels