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Glutathione-S-transferase activity in malarial parasites

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[DOI] [PubMed] [Google Scholar] 171.Agarwal A., Said T.M

Examples of moieties that can replace the phosphate linker include, but are not limited to, amides (e.g., amide-3 (3' -CH) 2 -C ( O) -n (h) -5 ') and amide-4 (3' -CH) 2 -n (h) -C ( O) -5 '), hydroxyamino, siloxane (dialkylsiloxane), carboxamide, carbonate, carboxymethyl, carbamate, carboxylate, thioether, oxirane linker, sulfide, sulfonate, sulfonamide, sulfonate, mercaptoformal (3' -S-CH), and the like 2 -O-5 '), methylal (3' -O-CH) 2 -O-5 '), oximes, methyleneimino, methylenecarbonylamino, methylenemethylimino (MMI, 3' -CH) 2 -N(CH 3 ) -O-5 '), methylene hydrazono, methylene dimethylhydrazono, methylene oxymethylimino, ether (C3' -O-C5 '), thioether (C3' -S-C5 '), thioacetamido (C3' -n (h) -C ( O) -CH 2 -S-C5C3-O-P(O)-O-SS-C5C3-CH 2 -NH-NH-C53-NHP(O)(OCH 3 ) -O-5 'and 3' -NHP (O) (OCH) 3 ) -O-5' and a mixture comprising N, O, S and CH 2 Non-ionic linkage of the component parts

Molecules smaller than 1.5 kD can pass through the MPTP unselectively