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In the seven-day week before treatment begins, patients will receive: At least five daily doses of folic acid One intramuscular injection of vitamin B12 A corticosteroid (dexamethasone) the day before, the day of and the day after treatment These supplements help reduce the incidence of side effects for patients

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In others an injection will be needed every 2 - 3 months

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Monitoring & Adjustment We retest B12 and symptoms, adjusting dose or frequency as needed to maintain optimal levels

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NADH levels can be increased in mitochondria by malate-aspartate and the glycerol-3-phosphate redox shuttles 14

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