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Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers

Recognizing the pathological impact of these multifaceted interactions provides a compelling rationale for therapeutically targeting this axis to reprogram anti-tumor immunitya strategy explored in the next section

During neuronal activation, increased Na + influx into astrocytes triggers rapid glycogen mobilization, leading to elevated intracellular glucose-6-phosphate levels and subsequent inhibition of hexokinase activity

2024 Mar 18];141(1):108-11

41589_2021_915_MOESM20_ESM.mpeg Supplementary Video 18 Representative movie for 100 ns MD simulation of GPX4 K48R with the camera zoomed in for a close-up of the active site