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Previous studies demonstrated that reduced melatonin levels provoked via ALAN may be involved in increased cancer incidence, especially hormone-dependent cancers (extensively reviewed in [100])

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Moreover, through mitochondrial transfer mechanisms such as tunneling nanotubes, extracellular vesicles, cell fusion, or gap junction channels, mutant mtDNA can be transmitted to other cells, serving as an important mode of intercellular communication within tumors

10.1016/j.cell.2012.06.023 Cell 252 WelfordR