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10.1111/j.1365-2036.2010.04347.x

45 Black pigmentation of the liver is thought to be secondary to defective secretion of epinephrine metabolites caused by MRP2 dysfunction

We found that 13% of ADC ( N = 515) and 18% of SCC ( N = 504) patients carried transcriptional alterations in ALDH1A1, ALDH1A3 , or ALDH3A1 with a mutually exclusive tendency, suggesting that these genes confer similar functional effects (Fig