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Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning

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This network underscores the essential role of bidirectional microbiotametaboliteimmune crosstalk in SLE and provides a rationale for targeted interventions (such as FMT, probiotics, metabolite supplementation, etc.), aiming to restore immune homeostasis through multiple pathways (Fig