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hLMNA-WT/R482L myoblast cell-type specific gene expression To find hLMNA-R482L-induced alterations in gene signatures we performed differential expression analysis between hLMNA-WT and hLMNA-R482L myoblasts in each cluster followed by analysis of pathways associated with differentially expressed genes (DEGs) enriched in clusters

355 The pro-inflammatory cytokines, in turn, augment both mitochondrial and NOX-generated ROS, contributing to further accumulation of oxidative damage (Fig

(5) The exposure of research models to AOD9604 has been suggested to restore -AR mRNA levels to those observed in lean controls

Mn-SOD, located in the mitochondria, and Cu/Zn-SOD, primarily found in the cytoplasm, play crucial roles in antioxidant defence

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