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Tesamorelin has completed randomized controlled trials and FDA approval for lipodystrophy, establishing robust clinical evidence

Key components that have been successfully manipulated on a regular basis to extend lifespan in short-lived model organisms are, e.g., the growth hormone/insulin-like growth factor 1 (GH/IGF1) system or the mechanistic target of rapamycin (mTOR) pathway (Laplante and Sabatini, 2012