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E x was normalized to E cr as [x] u /[cr] u , where x = Cd or pro, [x] u = urine concentration of x (mass/volume), and [cr] u = urine creatinine concentration (mg/dL)

However, it should be emphasized that the proposed mechanism of local decompression remains speculative, as intraosseous pressure changes or direct decompressive effects were not measured or directly tested in this study

After first vial puncture, many clinical settings recommend refrigeration at 28C (3646F) and following the manufacturers specified discard period

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