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GSK3 and PD-1 might regulate senescent podocytes via a comparable pathway since GSK3 is a pivotal upstream kinase, regulating PD-1 expression [51]

Nat Aca Sci U S A

Artif Cells Nanomed Biotechnol 45(8):14901495 Sperk M et al (2020) Utility of proteomics in emerging and re-emerging infectious diseases caused by RNA viruses

doi:10.1055/s-0037-1615780

Thus, it can be concluded that high-intensity exercises often have a negative effect on the integrity of the intestine, whereas low- and moderate-intensity regular exercise can have a positive effects