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This connection is also involved in the dimer stabilization (see below)

Lemerle E, Trompouki E

10.1159/000410231 58 RossiL.FraternaleA.BianchiM.MagnaniM

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Although rats have some physiologic differences from humans in the absorption, transport, and metabolism of vitamin B-12, these findings raise the alternative hypothesis that the effect of metformin on circulating vitamin B-12 concentrations is not due to the inhibition of absorption but rather due to the redistribution of vitamin B-12 among tissue compartments