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Although these drugs have significant effects in antitumor and other disease treatments, due to their lack of selectivity, they may also cause damage to normal cells, leading to side effects and drug resistance [474]

In necroptosis, RIPK3 interacts with RIPK1 and induces a necrotic cell death through MLKL or mitochondrial energy metabolism 10,11

As B 12 deficiency constrained in myelination, child develops varied cognitive and intellectual problems depending upon the area of the nervous system affected (Graber et al., 1971)

cit., p

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