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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

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Across six clinical trials involving over 900 participants, the side effect profile was described as indistinguishable from placebo

Gut permeability, inflammation, and metabolic disease

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