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Acrolein as an electrophile can induce the activation of Nrf2 independently of NADPH oxidase, by depletion of GSH [32], by limiting the enzymatic activity of thioredoxin, peroxiredoxins and other Nrf2 transcription targets, through adduct formation [70] and by potentially reacting with KEAP1 cysteine residues, promoting Nrf2-KEAP1 dissociation [31] [4]

One hundred ninety-one differentially expressed proteins involved in response to metal ions, neurofilament bundle assembly, and modulation of chemical synaptic transmission were identified between the MCAO model and DZXI groups after 7 days

doi: 10.3389/fncel.2022.889765 Received 04 March 2022 Accepted 19 April 2022 Published 19 May 2022 Volume 16 - 2022 Edited by Thorsten Roland Doeppner, University Medical Center Gttingen, Germany Reviewed by Fabien Gosselet, Universit dArtois, France

Enhanced assembly of these supramolecular structures demonstrates significant optimization of mitochondrial bioenergetics and augmentation of exercise performance (Champagne et al

& Bers, D