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Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)

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Access this article Similar content being viewed by others Abbreviations AM: Allyl meracaptan CaMK II: Calcium/calmodulin-dependent kinase II CDK: Cyclin dependent kinase Cyl: Cylindrocladium scoparium DADS: Diallyl disulfide DNMT: DNA methyltransferases ESCC: Esophageal squamous cell carcinoma GLUT-4: Glucose transporter type 4 HAT: Histone acetylases HC: Helminthosporium carbonum HDAC: Histone deacetylase HDACi: Histone deacetylase inhibitor HIF-1 : Hypoxia inducible factor 1 HSF-1: Heat shock factor-1 LAM-2: Lysosomal-associated membrane protein 2 NAD: Nicotinamide adenine dinucleotide NES: Nuclear export signal NF-B: Nuclear factor kappa B NLS: Nuclear localization signal PDGF: Platelet derived growth factor PEPCK: Phosphoenol pyruvate carboxykinase Psam A: Psammaplin A ROS: Reactive oxygen species SAHA: Suberanilohydroxamic acid SB: Sodium butyrate SFN: Sulforphane SIRT: Sirtuin SP: Sodium propionate TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand TSA: Trichostatin A VEGF: Vascular endothelial growth factor ZBG: Zinc binding group References Ahn MY, Jung JH, Na YJ, Kim HS (2008) A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

2.7 Pathogenesis of Alzheimers disease AD is driven by a complex interplay of genetic, molecular, and environmental factors, resulting in progressive neurodegeneration and cognitive impairment (Yuksel and Tacal, 2019)