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Symptoms may: Worsen after exposure to common triggers for asthma, e.g., pollen Improve after use of asthma medications May develop in patients with a known history of asthma or COPD Individuals with asthma-COPD overlap experience more symptoms, more frequent exacerbations, and higher mortality than individuals with either asthma or COPD alone

Arterioscler Thromb Vasc Biol 2016;36:10859

Animals also make more when stressed or exposed to viruses

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HO-1 is involved in a variety of pathological mechanisms of diabetic complications, especially inflammation and cell death caused by oxidative stress