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These changes can be reversible or persistent, and they play a central role in how diseases develop or are prevented across the lifespan

The use of Drosophila bring to the study of oxidative liver injury many advantages, including ease of genetic manipulation, availability of genetic mutants and constructs, ease of germ-free generation, relatively short lifespan, amenability to high-throughput screening, and overall cost relative to murine models 40

Given its multifaceted role, maintaining optimal glutathione levels is crucial for overall health

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The nuclear factor E2-related factor 2 (Nrf2)-related anti-oxidative stress is strongly associated with ferroptosis suppression