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showed that upregulation of HIF1- and its target genes was due to high methylation status of LIMD1 and VHL in cervical carcinoma [140]

Therefore, it is tempting to speculate whether NOTCH pathway activation and a resulting EMT may set these intrinsically chemotherapy resistant cells up to be ferroptosis responsive

But those nutrients might be affected by others

Gap junctions permit passage of water, ions, cellular second messengers, and other small molecules such as polypeptides and miRNA (Rodrguez-Sinovas et al., 2021)