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Therapeutic significance of estrogen receptor beta agonists in gliomas

Consistent with other central nervous system injuries, microglia activation in TBI results in different phenotypes, including the pro-inflammatory M1 (neurotoxic) and anti-inflammatory M2 (neuroprotective) phenotypes (Galgano et al., 2017)

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The Mediterranean diet, characterized by high intake of antioxidants and omega-3 fatty acids, improves metabolic homeostasis and reduces inflammation, thereby supporting reproductive competence [135]