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These reductions were accompanied by reduced species diversity [82]

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Recombinant E2 was also truncated at position 698

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PRC2 is thought to get locked on the mutant methionine residue, preventing it from moving along the chromatin to methylate adjacent wild-type histones, which reorganizes the methylation status at H3K27 across the genome with some areas showing loss and others gain of trimethylation. Overall, an altered methylome that has several downstream consequences for DIPG tumors