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The blockade of HMGB1 had achieved attenuation of experimental autoimmune myocarditis (EAM) by producing a significant decrease in myocardial fibrosis, which was significantly elevated in mouse serum in this study given by the fibrotic % (FB%: SMD: 3.25, 95%CI 0.77, 5.74, p = 0.01), in which the secretion of HMGB1 by myocardial fibroblasts as well as normal fibroblasts was also reported (105)

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Zinc (Zn), Iron (Fe), Lead (Pb), and Manganese (Mn) are released due to the burning of hair and effluents of the tanning industries (Hashem et al., 2017)