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Chronic IH can also result in an imbalance between pro- and antioxidant systems, ultimately leading to excessive ROS production and oxidative stress in ECs [156]

If there was anything he learned, its that optimism is the way

For example, HIF1- and HIF2-dependent transcriptional programmes have been linked to metastatic progression in several tumour types, 123,124,125,126 suggesting that activation of the hypoxia response in primary tumours might be important for metastatic tumour growth in the secondary organs

Everything else is secondary to that