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J Neurosci Res 67:772780

Baumgarten, S

GCL forms an unusual peptide bond between the -carboxyl of glutamate and the amino group of cysteine using the energy provided by the hydrolysis of ATP (Lu, 2013)

Therefore, chronic activation of the NLRP3 inflammasome promotes fibroblast differentiation into MYFs, which results in excessive collagen deposition and tissue scarring, contributing to chronic inflammation and fibrosis [169, 170]