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In general, it can be concluded that proper nutrition which promotes a healthy biodiversity of the gut microbiota, combined with moderate exercise, contribute to the integrity of the intestine

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doi:10.1016/j.drugalcdep.2012.01.013 7

Failure of autophagy in this context promotes the accumulation of oxidative stress, aberrant signaling, mitochondrial damage, and chronic inflammation, collectively establishing a pro-tumorigenic cellular environment