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Doses are usually low and delivered in short pulses or continuous infusion based on effect needed, which makes stimulation targeted and controllable compared to more general agents

Any deviation shortens that window proportionally

4,171 The participant is then instructed to alter the signals in a certain way, and is rewarded with positive feedback when they are successful

That is a combination that is rarely, if ever, seen (likely incompatible with life)

[1] If clinical suspicion is high, particularly with subacute combined degeneration, treatment should commence immediately as delays may result in irreversible damage