Oxidative stress in the RPE, induced by ROS such as hydrogen peroxide, is hypothesized to be an important driving force in the progression of this disease [16]
These methods offer high sensitivity and resolution, enabling detailed analysis of metabolites and enhancing our understanding of cellular metabolic pathways and their roles in health and disease [274]
The mutual regulatory role of ferroptosis and immunotherapy in Anti-tumor therapy
Access this article Similar content being viewed by others Data Availability Not applicable Abbreviations ACE2: Angiotensin-converting enzyme 2 AD: Alzheimers disease ANA: Antinuclear antibodies ANCA: Antineutrophil cytoplasmic antibodies AOSD: Adult-onset Stills disease ASD: Autism spectrum disorders BBB: Blood-brain barrier CA: Carnosic acid CFS: Chronic fatigue syndrome CNS: Central nervous system COVID-19: Coronavirus disease 2019 ED: Emergency department DSF: Disulfiram FTD: Frontotemporal dementia GPX1: Glutathione peroxidase 1 GSH: Glutathione GSTM1: Glutathione S-transferase mu 1 IIM: Idiopathic inflammatory myopathies KEAP1: Kelch-like ECH-associated protein 1 MC: Mast cell nEVs: Neuron-enriched extracellular vesicles NF-: Nuclear factor kappa beta NFL: Neurofilament light chain NLRP3: NLR family pyrin domaincontaining 3 NRF2: Nuclear factor erythroid-related factor 2 NRP1: Neuropilin-1 OCR: Oxygen consumption rate OPC: Oligodendrocyte progenitor cells POTS: Postural orthostatic tachycardia syndrome ROS: Reactive oxygen species SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 SLE: Systemic lupus erythematosus SM: Systemic mastocytosis SOD: Superoxide dismutase SR: Coronavirus spike protein receptor THT: Thioflavin T aggregation assay References Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ (2021) 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records
These pathways influence the expression of adipocyte-specific transcription factors, including PPAR, C/EBP, and SREBP, which regulate lipid metabolism and adipocyte differentiation
