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When diet is not an issue, B12 deficiency generally has to do with an inability to absorb the vitamin properly

doi: 10.3389/fimmu.2019.00760 Received 24 October 2018 Accepted 21 March 2019 Published 24 April 2019 Volume 10 - 2019 Edited by Nurit Hollander, Tel Aviv University, Israel Reviewed by Alessandra Romano, Universit degli Studi di Catania, Italy

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A similar lack of endocrine IGF-II effects on growth and metabolism was reported in the IGF-I deficient child mentioned previously with a loss of exon 4 of the IGF1 gene