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The biofilm stimulation with M4 peptide caused an increase in GPX3 and SOD5 mRNA level by 3.3- and 12.2-fold, respectively (Figure 7C)

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There are now multiple studies confirming these hypotheses, especially mGluR5s activation and downstream signal transduction hypersensitivity as critical pathogenic factors in FXS (Dolen & Bear, 2008