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doi: 10.1111/jcmm.13688

It has been demonstrated that administration of GluN2B-specific inhibitors, ifenprodil and conantokin-G, ameliorates ischemia-mediated infarct size and neuronal death by decreasing neurological deficits, restoring cytoarchitecture, and increasing the expression of pro-survival CREB molecules 69,70

In the same study, this ITPA genotype was associated with clinical effectiveness [62]

THEREFORE, VALPROATE SHOULD BE CONSIDERED FOR WOMEN OF CHILDBEARING POTENTIAL ONLY AFTER THE RISKS HAVE BEEN THOROUGHLY DISCUSSED WTH THE PATIENT AND WEIGHED AGAINST THE POTENTIAL BENEFITS OF TREATMENT